Liver disease

liver disease

Here you can navigate to find more information on how various liver diseases and liver failure affect brain function, leading to the neurological and psychiatric alterations characteristic of hepatic encephalopathy (HE).1,2

Early detection and intervention increasingly important as the cognitive and psychomotor impairment associated with HE has serious health, social and economic consequences.1,2 The mechanisms responsible for the neurological alterations in HE are beginning to emerge and therapeutic strategies targeting neurotoxic ammonia improve symptoms, functioning and patient quality of life.3,4


1. Felipo V. Hepatic encephalopathy: effects of liver failure on brain function. Nat Rev Neurosci. 2013;14(12):851-8.
2. Poordad FF. Review article: the burden of hepatic encephalopathy. Aliment Pharmacol Ther. 2007;25 Suppl 1:3-9.
3. Poo JL et al. Efficacy of oral L-ornithine-L-aspartate in cirrhotic patients with hyperammonemic hepatic encephalopathy. Results of a randomized, lactulose-controlled study. Ann Hepatol. 2006;5(4):281-8.
4. Ong JP et al. Oral L-ornithine-L-aspartate improves health-related quality of life in cirrhotic patients with hepatic encephalopathy: an open-label, prospective, multicentre observational study. Clin Drug Invest. 2011;31(4):213-220.